I’ll go first. Mine is the instant knockout drug. Like Dexter’s intramuscular injection that causes someone to immediately lose consciousness. Or in the movie Split where there’s the aerosol spray in your face that makes you instantly unconscious. Or pretty much any time someone uses chloroform.
It doesn’t bother me so much when a character in a show has to take a turn with the idiot ball, but when a video game wants me to hold the idiot ball it really makes me want to stop playing. Recently I was checking out Fallen Leaf and the very first level ends with a character politely but firmly indicating that I can’t go further in this random cave I’m exploring, because there’s something dangerous stored there… while standing under a stalactite that the game clearly wants you to drop on them. No, god damn it, I am not going to commit murder just to unleash the ancient evil that I would clearly spend the rest of the game stopping. I can just quit here and not be a murderer and the world can stay safe.
I did not even humor it by hitting the stalactite to see what happens, I just pressed alt-F4 and went to play something else.