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Cake day: March 31st, 2025

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  • not an immunologist; i don’t want to undersell this to you: immunology is fantastically complex subject with many redundancies, feedback loops, and frustrating number of moving parts, many of which are still unknown in sufficient detail. that said, if you want any chance for it to go: first you’d have to figure out what exactly mealses virus does, then you’d have to find a disease that can be cured or treated by obliterating whatever mealses virus is obliterating, and then if there’s any match (big if) it’ll probably still won’t work just with wild type virus and require significant modifications. and even then, that effect as is known in mealses today is not very reliable and lasts only months to years. and even then, there might be other approaches that are safer or more reliable or both

    maybe in the course of figuring the first one there will show up an option to modify mealses virus in some significant way that might allow it to target something else, and maybe target other kind of disease, because in no way it’d be a blanket cure for all immune diseases ever. maybe someone made an observational study already that tracked how prevalence of some immune diseases changes after mealses infection, but many of these are rare diseases and it’d be massively hard endeavor


  • I think it would be comparable to situation where all mRNA is suddenly unusable, ie protein synthesis can’t run at all. This would be something like ricin or diphteria toxin poisoning, but instead of being limited to gastrointestinal lining it’s spread all over. I’d guess hours to days before anything visible starts happening (symptoms only start to appear when deficit in new protein synthesis becomes noticeable; all protein already made continues to work for sone time)






  • sounds like it’s not supposed to be a general use tool, but instead for counterintelligence only:

    The Ministry of the Interior anticipates submitting around 30 requests per year for the surveillance of unencrypted messages and between 5 to 15 requests for encrypted communications. If there are 30 instances of encrypted message monitoring within a single calendar year, the Interior Minister is obligated to inform a permanent subcommittee of the National Council, which is the directly elected chamber of the Austrian Parliament.

    Each surveillance method will require case-by-case approval from the Federal Administrative Court. The process involves a legal protection officer from the Ministry of the Interior, who will have three business days to respond to any request. Following that, a panel of three judges from the Federal Administrative Court will review the case. In urgent situations, an individual judge may grant approval, supported by a 24-hour judicial service system.

    https://themunicheye.com/austrian-government-approves-malware-surveillance-23431

    broad use would expose its existence and make any 0days useless in short order



  • in many flats even recently built you don’t get three-phase power, just single phase, but building divides single three-phase supply into three groups of single phase circuits like you say (do you really need 20kW in residential flat? one that doesn’t use EV charger, built in 90s-10s?) i guess it depends on country also. separate houses tend to get three phase connection where i live

    floating neutral will also be a problem in american-type two-phase installation, might be even worse (more frequent) on account of large number of lightly maintained transformers used (why on gods green earth there’s few-kV medium voltage line going down every street, americans make it make sense)




  • you don’t have to have three phase circuit to be affected by floating neutral in three-phase substation upstream. in some places in us there are 208v interphase three-phase circuits, which give 120v phase to neutral, which is distributed as a pair of wires as single-phase circuit. this is also normal way to deliver single-phase power in europe, as it’s most efficient use of conductor. (from 400v three-phase circuits) in case more power is needed than single-phase circuit can deliver, three-phase circuit is installed

    if there’s switch on device, it’s 2p1t meaning both phase and neutral are switched. if it’s permanent, non-pluggable circuit, like lightning, it’s okay if only phase is switched (neutral is connected permanently)


  • it’s a bad practice to design appliance in such a way to assume that neutral will have low voltage, because in case of neutral failure in three-phase circuit you can get full voltage there, and there can be a couple of volts difference (sometimes more) between neutral and ground even in normal circumstances

    it’s better to cut off both live and neutral at the same time anyway, especially if there’s no standard which is which. also, as device designer you don’t know if it’ll be used on a circuit that has neutral and phase where you think it’ll go or not. (ie british appliance used on unpolarized circuit, like type F. adapters exist)